The Multilateral Development Banks (MDBs) are going through a process of adjustment before two (2) significant changes that condition their performance: The unprecedented technological revolution, especially in computer and information technologies; and the incremental complexity of core development agenda issues. Both spheres pose a challenge for these institutions in terms of increasing their efficiency, versatility, and adaptability to change in their operating contexts. In this sense, the improvement of territorial analysis methods has become a particularly useful support in the work of MDBs to improve their analytical capacity, the management of their operations and the monitoring and evaluation of their impacts. Used properly, territorial analysis tools can become key elements in improving the performance of MDBs in Latin America and the Caribbean, which will result in benefits for their partner countries.